In the early 2000 timeframe, nitrogen-Di-Water foggers were introduced using liquid nitrogen and pure water ( de-ionized water, WFI water and sterile water) to produce a very dense, pure fog to conduct DI Water for smoke studies. The AP35, AP50, AP100 and AP150 are the high volume, nitrogen foggers from Sistema, which includes adjustable airflow control, adjustable fog volume, wireless remote control and 12 effective accessories. Smoke Study foggers support smoke studies and airflow visualization studies to characterize airflow patters, uniformity and turbulence in clean rooms, medical rooms, ISO suites, sterile rooms, barrier isolators, glove boxes, airflow hoods and fume hoods. Portable fogger, DI water fogger and Glycol foggers are also called smoke machines or smoke generators, and are used in smoke studies and air flow visualization characterization of clean rooms, ISO suites, sterile rooms, BSC, Barrier Isolators, fume hoods, airflow hoods, bio safety cabinets, glove boxes, ISO Suites, etc. The portable fogger is available for smoke studies in clean rooms, ISO suites, barrier Isolators, glove boxes and sterile rooms. Please review performance comparison below and click on product links in chart on left. Call Applied Metrology LLC at 720-635-3931

Smoke Studies and Airflow Visualization Comparisons

Fogger Model Number Enclosure Material Fog Application Fog Volume Minute Duration in Minutes Fog View Distance Appx. Fog Volume Fog Outlets Velocity Control Volume Control Accessories
Polyethylene Enclosure, Push Button Control, Large Red LED displays, Water Level Interlocks, Wireless capable
2×4 Airflow Hoods & Fume Hoods
≈ 0.5 M³ / Min.
≈ 45 Min., Pure Fog
≈ 6-7 Feet visual distance w/ 1 80mm Fog Hose + 1 0.6M Fog Rake
≈ 22.5 M³
One 80mm Fog Outlet
Yes
No
Wireless Control, 350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 80mmx3M Fog Hose, 3Mx50mm Fog Hose, T Adaptor, Y Adaptor, etc., 4 Color LED Fog Light, Video Camera
316 Stainless Steel Design, Touch Pad Control, small White LED Display
2×6 Airflow Hoods, Gloveboxes, BSCs
≈ 0.7 M³ / Min.
≈ 45 Min., Pure Fog
≈ 7-8 Feet visual distance w/ 1 80mm Fog Hose + 1 0.6M Fog Rake
≈ 32 M³
One 80mm Fog Outlet
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
316 Stainless Steel Design, Touch Pad Control, small White LED Display
2×8 Airflow Hoods, Gloveboxes, BSCs
≈ 0.83 M³ / Min.
≈ 45 Min., Pure Fog
≈ 8-9 Feet visual distance w/ 1 Y Adaptor + 2 80mm Fog Hoses + 2 0.6M Fog Rakes
≈ 37 M³
One 80mm Fog Outlet
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
316 Stainless Steel Design, Touch Pad Control, small White LED Display
2×10 Airflow Hoods, BSC & Small Barrier Isolators, Medium Glovebox
≈ 1 M³ / Min.
≈ 45 Minutes Typical Operation Time w/ Pure Fog
≈ 10-11 Feet visual distance w/ 1 Y Adaptor + 2 80mm Fog Hoses + 2 0.6M Fog Rakes
≈ 45 M³
One 80mm Fog Outlet
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
316 Stainless Steel Design, Touch Pad Control, small White LED Display
2×10 Airflow Hoods, BSC & Small Barrier Isolators, Medium Glovebox
≈ 1.4 M³ / Min.
≈ 45 Minutes Typical Operation Time w/ Pure Fog
≈ 11-12 Feet visual distance w/ 2 Y Adaptors + 4 50mm Fog Hoses + 4 1.2M x 50mm Fog Rakes
≈ 63 M³
One 80mm Fog Outlet
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
316 Stainless Steel Design, Touch Pad Control, small White LED Display
2×12 Airflow Hoods, BSC & Small Barrier Isolators, Medium Glovebox
≈ 2.0 M³ / Min.
≈ 35 Minutes Typical Operation Time w/ Pure Fog
≈ 13-15 Feet visual distance w/ 2 Y Adaptors + 4 50mm Fog Hoses + 4 1.2M x 50mm Fog Rakes
≈ 70 M³
Two 80mm Fog Outlets
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
M2001 / M2100 *** Nitrogen-Di-Water Fogger, Carry by Hand using Handles
316 Stainless
BSC & Barrier Isolator
≈ 1.5 M³ / Min.
≈ 35 Minutes Typical Operation Time w/ Ultrapure Fog
≈ 7-10 Ft. Feet Visual Distance w/ 1 fog rake
≈ 52.5 M³
One 60mm Outlet
None
None
None
316 Stainless Steel Design, 35 L Liquid Nitrogen Dewar, 11.5 L Water Cavity w/ Dual Water Heater, Small White LED Display, Touchpad Control
Small DI Water Foggers, Small ISO Suites, Medium Barrier Isolators, Glove Boxes
≈ 5 M³ / Min.
≈ 45 Minutes Typical Operation Time w/ Ultrapure Fog
≈ 10-15 Feet visual distance w/ 1 Y Adaptor + 2 80mm Fog Hoses + 2 1.2 M Fog Rakes
≈ 225 M³
One 80mm Fog Outlet
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
316 Stainless Steel Design, 50 L Liquid Nitrogen Dewar, 13.5 L Water Cavity w/ Dual Water Heater, Small White LED Display, Touchpad Control
Small DI Water Foggers, Small ISO Suites, Medium Barrier Isolators, Glove Boxes
≈ 8 M³ / Min.
≈ 60 Minutes Typical Operation Time w/ Ultrapure Fog
≈ 15-18 Feet visual distance w/ 2 Y Adaptors + 4 50mm Fog Hoses + 4 1.2 M x 50mm Fog Rakes
≈ 480 M³
One 80mm
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
316 Stainless Steel Design, 100 L Liquid Nitrogen Dewar, 13.5 L Water Cavity w/ Dual Water Heater, Small White LED Display, Touchpad Control
Medium DI Water Foggers, Medium ISO Suites, Medium Barrier Isolators, Large Glove Boxes and BSCs
≈ 16 M³ / Min.
≈ 80 Minutes Typical Operation Time w/ Ultrapure Fog
≈ 18-21 Feet visual distance w/ 2 Y Adaptors + 4 50mm Fog Hoses + 4 1.2 M x 50mm Fog Rakes
≈ 1280 M³
Two 80mm Fog Outlets
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
316 Stainless Steel Design, 150 L Liquid Nitrogen Dewar, 13.5 L Water Cavity w/ Dual Water Heater, Small White LED Display, Touchpad Control
Large DI Water Foggers, Large ISO Suites, Large Barrier Isolators, Glove Boxes and BSCs
≈ 24 M³ / Min.
≈ 120 Minutes Typical Operation Time w/ Ultrapure Fog
≈ 22-25 Feet visual distance w/ 3 Y Adaptors + 6 50mm Fog Hoses + 6 1.2 M x 50mm Fog Rakes
≈ 2880 M³
Three 80mm Fog Outlets
Yes
Yes
350mm Nozzle, 0.6mx80mm fog wand, 1.2mx80mm Fog Wand, 0.6Mx50mm Fog Wand, 1.2Mx50mm fog wand, 5Mx80mm Fog Hose, 5Mx50mm Fog Hose, T Adaptor, Y Adaptor, Video Camera
* Smoke Study Foggers use De-Ionized Water, Water for Injection or Sterile Water
** Nitrogen-Di-Water Fogger in Smoke Studies uses liquid nitrogen + De-Ionized Water, Water for Injection or Sterile Water
*** liquid nitrogen fogger from 2000 time frame

Nitrogen-Di-Water foggers are quite effective in producing a visible fog to visualize airflow patterns, airflow uniformity. These foggers came into use in the early 2000 time frame in smoke studies, replacing smoke sticks and CO2 fog pots. Smoke sticks, by definition, produce a smoke, which is chemical/heat induced smoke composed of particulate smoke. In modern ISO Suites and Clean Rooms, smoke sticks would be banned by most Metrology Engineers in 2025. CO2 fog is produced by producing CO2 ice, and dropping it into a warm water bath, allowing the CO2 to evaporate and combine with water vapor to form a dense fog. Yet a CO2 fog, although rather simple to produce, does not allow for volume control or velocity control, as do more recent fogger technology. 

More recent fogger technology has been put into use, referred to as DI Water Foggers, Portable foggers and Nitrogen-Di-Water foggers. The more recent fogger technology incorporates fog volume control, velocity control of the fog output and wireless remote control, all which are important control elements to evaluate the airflow performance in a smoke study.

Of these different foggers, the Nitrogen-Di-Water foggers produce the most fog density and fog volume for smoke studies; while ultrasonic foggers produce the less fog, they are easier to operate and set up for operation in a smoke study. The four Nitrogen-Di-Water foggers compared above are the AP35, AP50, AP100 and AP150, produced in Germany by Sistema, offered by Applied Metrology. Each of these foggers operate the same with velocity control, water temperature control and fog volume control; the only difference being the volume of the liquid nitrogen Dewar at 35 L, 50 L, 100 L or 150 liters.

For discussion, we will refer to the AP35 Nitrogen-Di-Water fogger, which produces about 5 cubic meters dense fog per minute, and includes a rolling trolley for easy movement around a clean room or ISO Suite. It uses 11.5 liters water and 35 liters liquid nitrogen to produce fog over a typical 45 minute fog cycle. The AP35 Nitrogen-Di-Water fogger provides adjustable fog volume, adjustable fog velocity, and it also includes an optional wireless remote control Key FOB. The AP35 produces an dense, paper white fog at about 2-3 micron fog droplet diameter with very high fog density, where as the typical ultrasonic fogger produces larger fog droplets from 5 to 8 microns but at much lower fog density. The AP35 Nitrogen-Di-Water fogger can visualize airflow turbulence and balance airflow between rooms. The Nitrogen-Di-Water fog is generated by heating water to form water vapor, and then allowing nitrogen vapor to combine with the water vapor to form a very dense fog at much smaller droplet diameters.  Water vapor combined with Nitrogen vapor forms a 2-3 micron diameter fog vapor droplet. Liquid Nitrogen readily boils at room temperatures, producing high volume of nitrogen vapor. The older Nitrogen-Di-Water foggers of 2001 vintage had no adjustable controls, which is why the older smoke generators are being replaced with newer ultrasonic and Nitrogen-Di-Water technology with adjustable controls, making the AP35, AP50, AP100 and AP150 very effective tools in smoke studies in ISO Suites and clean rooms.

The chart above compares the ultrasonic and Nitrogen-Di-Water fogger used today in smoke studies around the world. The SMST-12 is the lower cost, entry level fogger, and used in small volumetric smoke studies such as 2×4′ airflow hoods and in fume hood airflow studies. As you go down the table, each ultrasonic and Nitrogen-Di-Water fogger shows performance attributes, which help metrology engineers and airflow technicians identify the smoke machine  that best supports their smoke study requirements.

The ultrasonic fogger with the highest fog volume per minute is the AFM40 ultrasonic fogger. It is a very effective portable fogger, quick to set up for a smoke study and has two 80mm fog outlets so that a maximum amount of pure fog is emitted for a typical smoke study in a barrier isolator or small ISO Suite airflow visualization test.  The AP35 is the next step up if fog volume, fog density and fog purity, followed by the AP50, AP100 and AP150. All of the AP series Ultrapure Foggers use DI (de-ionized) water, WFI (water for injection) or sterile water; and also uses Liquid Nitrogen to produce an ultrapure fog. The AP35 uses 35 liters Liquid Nitrogen, the AP50 uses 50 liters Liquid Nitrogen, AP100 uses 100 liters of Liquid Nitrogen, while the AP150 uses 150 liters of Liquid Nitrogen. Each of these foggers provide a Control Unit, that includes a 13.5 liter water cavity, combined with water temperature control and fog velocity control and fog volume control.

The higher the fog density, the more visual fog distance is provided, and our AP35 provides 2 times more fog density than our best AFM40 Ultrasonic Fogger. Our Nitrogen-Di-Water foggers produce the highest fog volumes with the most fog purity, combined with useful accessories to conduct smoke studies in your clean rooms and ISO suites. The AP100 Liquid Nitrogen Nitrogen-Di-Water Fogger produces 16 cubic meters a minute of dense paper white fog and provides two 5M x 80mm fog outlets, while the AP150 provides up to 24 cubic meters of dense, paper white fog per minute and offers three 80mm fog outlets. hose outputs. Our Nitrogen-Di-Water foggers are designed for high volume, dense paper white fog with controllable fog output and 12 different accessories for use in a smoke study.

Some companies and engineers do not want to use liquid nitrogen or do not have access to it. If you do not want to use liquid nitrogen,  but want high volume fog, consider the AFM40 Smoke Studies Fogger. The AFM40 is an ultrasonic fogger and provides about 2 cubic meters of pure fog per minute for about35-40 minutes through two 80mm fog outlets, providing 13-15 feet of visual airflow using the appropriate fog wands and 80mm hoses. It provides an adjustable fog volume and airflow velocity, touch pad control and wireless remote control. Alternatively, we provide our SMST-12 Smoke Studies Fogger for low cost solutions to provide airflow visualization in 2×4′ fume hoods, Bio-Safety Cabinets and Aseptic Isolators. Our ultrasonic and nitrogen foggers are priced according to fog volume produced. 

It does not make sense to buy a smoke generator unless you match the fog output to your smoke study requirements. If you do not know how much fog volume is needed for a smoke study, and if you have varying requirements for fog volume, consider the AFM40 or AFM35 Smoke Study Foggers. These foggers use ultrasonics to produce fog, thus have a simple set up sequence to conduct an airflow visualization study. Use De-ionized water, Distilled water, WFI water or sterile water, or any pure pharmaceutical water. DI-water foggers are more simple to operate but produce less fog and fog density than our Nitrogen-DI-Water foggers. Our SMST-12 Smoke Studies Fogger support airflow visualization and airflow recovery tests as defined by ISO 14644-3, B12. The AFM40 Smoke Studies Fogger is ideal for airflow visualization in clean rooms, ISO suites, medical operating rooms and sterile rooms. Contact Applied Metrology LLC at TEL: 1-720-635-3931 or 1-303-999-6837.

AP50 Nitrogen-Di-Water Fogger provides around 7.5 cubic meters of dense, paper white fog to visualize airflow turbulence, airflow patterns, direction and to locate dead airflow zones. The AP50 Nitrogen-Di-Water Fogger, AFM40 Smoke Study Fogger and SMST-12 Smoke Studies Fogger support ISO 14644-3, USP 797 Insitu Airflow Analysis, Federal Standards 209E and ISO 1446 for clean rooms; as well as USP 800 for Compound Pharmacy. The video above is from Sistema using the original AP32 Nitrogen-Di-Water Fogger.

AP50 Nitrogen-Di-Water Fogger supports USP 797, ISO 14644-3, Annex B.7, Federal Standards 209E and ISO 1446 for airflow visualization studies.

The AP50 Nitrogen-Di-Water Fogger is designed with a 316L Stainless Steel body and enclosure and electro-polish finish. Nitrogen-Di-Water Foggers are used in smoke studies of ISO suites, sterile rooms and clean rooms that require higher volumes of fog, high fog density and long visual airflow distances. Also referred to as liquid nitrogen foggers, it can visualize airflow, turbulence, patterns, direction and to locate dead airflow zones in Class 1 to Class 100,000 clean rooms.

SMST-12 Smoke Studies Fogger, supports airflow visualization studies, and supports Airflow Recovery tests (ISO 14644-3, Annex B.12 Airflow Recovery Tests) using 0.5 micron or 1 micron PSL Spheres

SMST-12 Smoke Studies Fogger
Smoke Studies

SMST-12 Smoke Studies Fogger is primarily used in in smoke studies and air flow characterization of fume hoods; and can also be used in airflow recovery tests using 0.5 micron or 1 micron polystyrene latex spheres.  The SMST-12 portable fogger provides 0.5 cubic feet of pure fog per minute for about 45 minutes with 6-7 feet of visual airflow distance. The fog is a constant volume output combined with the PSL Spheres. Using a laser particle counter, you can access how fast the PSL Spheres travel through the airflow and out to the exhaust. LOW COST, DI Water Fogger to visualize clean room airflow providing 0.5 cubic meters of pure fog for 50 minutes.

SMST-12 Operating Instructions
SMST-12 Side view

The AFM30 Smoke Studies Fogger supporting airflow visualization studies in 2×10′ Airflow Hoods, BSC and Bio-Safety Cabinets, Barrier Isolators and medium-sized Glove Boxes.

The AFM30 Smoke Studies Fogger is a portable fogger with 30 ultrasonic piezos, and the enclosure and water cavity is designed with a 316L Stainless Steel body and enclosure and electro-polish finish. It is used in smoke studies and airflow characterization tests of fume hoods and aseptic pharmacy isolators and small ISO-Suites. The AFM30 Smoke Studies Fogger provides airflow velocity control, fog volume control and water level feedback via a LED display and touch pad control. The fog volume is constant at any of 3 levels of fog volume. Touch pad control is provided and a Remote Wireless Control is optionally available for operation behind a closed wall. The AFM30 is ideal to conduct airflow visualization studies and visualize airflow turbulence in the airflow.

CO2 Smoke Study Fogger

A CO2 Fogger is a very basic tool to produce CO@ fog smoke in a smoke study by combining warm water and CO2 ice.

Portable Ultrasonic Foggers and Nitrogen-DI-Water Foggers

Type of portable fogger are provided, using a battery to provide power to produce a portable fog. The ultrasonic fogger uses deionized water or WFI water with ultrasonic piezos to produce a dense fog.

AP50 Ultrapure Fogger uses liquid nitrogen and Deionized Water, sterile water or WFI water, Water for Injection, to create the highest fog density for ultrapure fog to provide superb video and visualization of airflow patterns, direction, turbulence, dead zones and velocity. The AP50 produces up to 7.5 cubic meters of ultrapure fog per minute to provide around 12-15 feet of visual airflow for up to 50 minutes per cycle. We also provide the higher volume nitrogen foggers AP150. Each AP series ultrapure foggers provides velocity control, volume control and has optional wireless remote control.  No contamination is created in a nitrogen based fogger. Thus cleaning up after a smoke study is minimal. The AP35, AP50, AP100 and AP150 are modular in design providing simple operation and maintenance for smoke studies guided by ISO 14644-3, Annex B.7 Airflow Direction Test and Visualization; USP 797 Insitu Airflow Analysis, and Semi-Standards Clean Room guidelines.

Our Ultrasonic foggers use de-ionized water, Sterile water or water for injection  water to produce from 0.5 to 2.0 cubic meters fog per minute, depending on which fogger you use in your smoke study. The AFM Cube, AFM24, AFM30, AFM35, AFM40 Ultrasonic Foggers have an internal power supply, power cord for 110VAC or 220VAC, 80mm or 50mm fog hose, LED display, optional remote control using a Wireless Remote Control Fob. Operational control includes airflow velocity, fog volume control (by turning on additional transducers), and an LED display alerts to the LED display for water level feedback. Fog output has an “on demand” fog control for about 40 minutes. Clean room airflow, turbulence, patterns and balance of airflow in smoke studies of Pharmaceutical ISO suites, sterile rooms and aseptic isolators to support clean room guidelines: ISO 14644-3, Annex B.7 Airflow Direction Test and Visualization; USP 797 Insitu Airflow Analysis; and Semi-Standards Clean Room guidelines for airflow visualization and analysis.

SMST-12 DI Water Fogger is used in smoke studies using DI Water or WFI (water for injection) water to produce 0.5 cubic meters fog per minute for about 50 minutes, and provides about 6-7 feet of visual fog in the airflow. The SMST-12 has an internal universal power supply supporting 110VAC, 220VAC and 100VAC at 50 and 60 Hz, and provides 48Vdc power to the ultrasonic transducers. The power cable supplied supports the customers local voltage requirements. The fog outlet is 80mm wide and there are about 12 different fog accessories available for use in your smoke studies, including optional wireless remote FOB, 80mm fog rakes and 60mm fog wands, optional rolling carry & storage case. Fog output is ‘on demand’ using push button control or wireless control maximum fog cycle is about 50 minutes. Cold 40-45 F water is used for fill and refill. With a water refil, fog can be started immediately. No contamination of any kind is created and no clean up is required. Clean room airflow, turbulence, patterns and balance of airflow in smoke studies of Pharmaceutical ISO suites, sterile rooms and barrier isolators to support clean room guidelines: ISO 14644-3, Annex B.7 Airflow Direction Test and Visualization; Annex B.12 Airflow Recovery Test; USP 797 Insitu Airflow Analysis; and Semi-Standards Clean Room guidelines for airflow visualization and analysis.

DI Water Fogger is common term for clean room foggers and smoke study visualization. It provides airflow visualization of turbulence and dead spots in clean rooms, sterile rooms and ISO suites. No contamination is created and no clean up afterwards is required. Distilled Water or Water for Injection (WFI) is converted to a pure fog vapor for about 50 minutes at 9cfm fog volume to support guidelines for ISO 14644-3, Annex B.12 Airflow Recovery Test using 0.5 micron PSL or 1 micron PSL spheres.